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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpelainen, TO (author)
University of Copenhagen,Icahn School of Medicine at Mount Sinai
Bentley, AR (author)
Noordam, R (author)
show more...
Sung, YJ (author)
Schwander, K (author)
Winkler, TW (author)
Jakupovic, H (author)
Chasman, DI (author)
Manning, A (author)
Ntalla, I (author)
Aschard, H (author)
Brown, MR (author)
de las Fuentes, L (author)
Karolinska Institutet
Franceschini, N (author)
Guo, XQ (author)
Vojinovic, D (author)
Aslibekyan, S (author)
Feitosa, MF (author)
Kho, M (author)
Karolinska Institutet
Musani, SK (author)
Richard, M (author)
Wang, HM (author)
Wang, Z (author)
Bartz, TM (author)
Bielak, LF (author)
Campbell, A (author)
Dorajoo, R (author)
Fisher, V (author)
Franks, Paul (author)
Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University
Horimoto, ARVR (author)
Li, CW (author)
Lohman, KK (author)
Marten, J (author)
Sim, XL (author)
Smith, AV (author)
Tajuddin, SM (author)
Alver, M (author)
Amini, M (author)
Boissel, M (author)
Chai, JF (author)
Chen, X (author)
Karolinska Institutet
Divers, J (author)
Evangelou, E (author)
Gao, C (author)
Washington University in St. Louis
Graff, M (author)
Harris, SE (author)
He, MA (author)
Hsu, FC (author)
Jackson, AU (author)
Zhao, JH (author)
Kraja, AT (author)
Kuhnel, B (author)
Laguzzi, F (author)
Karolinska Institutet
Lyytikainen, LP (author)
Karolinska Institutet
Nolte, IM (author)
Rauramaa, R (author)
Riaz, M (author)
Robino, A (author)
Rueedi, R (author)
Stringham, HM (author)
Takeuchi, F (author)
van der Most, PJ (author)
V. Varga, Tibor (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
Verweij, N (author)
Ware, EB (author)
Wen, WQ (author)
Li, XY (author)
Yanek, LR (author)
Amin, N (author)
Arnett, DK (author)
Boerwinkle, E (author)
Brumat, M (author)
Cade, B (author)
Canouil, M (author)
Chen, YDI (author)
Concas, MP (author)
Connell, J (author)
de Mutsert, R (author)
de Silva, HJ (author)
de Vries, PS (author)
Demirkan, A (author)
Ding, JZ (author)
Eaton, CB (author)
Faul, JD (author)
Friedlander, Y (author)
Gabriel, KP (author)
Ghanbari, M (author)
Giulianini, F (author)
Gu, CC (author)
Gu, DF (author)
Harris, TB (author)
He, J (author)
Heikkinen, S (author)
Heng, CK (author)
Hunt, SC (author)
Ikram, MA (author)
Jonas, JB (author)
Wennberg, Patrik, 1972- (author)
Umeå universitet,Allmänmedicin
Komulainen, P (author)
Krieger, JE (author)
Kritchevsky, SB (author)
Kutalik, Z (author)
Kuusisto, J (author)
Langefeld, CD (author)
Langenberg, C (author)
Launer, LJ (author)
Leander, K (author)
Karolinska Institutet
Lemaitre, RN (author)
Lewis, CE (author)
Liang, JJ (author)
Alizadeh, BZ (author)
Boezen, HM (author)
Franke, L (author)
Icahn School of Medicine at Mount Sinai
Navis, G (author)
Rots, M (author)
Swertz, M (author)
Wolffenbuttel, BHR (author)
Wijmenga, C (author)
Liu, JJ (author)
Magi, R (author)
Manichaikul, A (author)
Meitinger, T (author)
Metspalu, A (author)
Milaneschi, Y (author)
Mohlke, KL (author)
Mosley, TH (author)
Murray, AD (author)
Nalls, MA (author)
Nang, EEK (author)
Nelson, CP (author)
Nona, S (author)
Norris, JM (author)
Nwuba, CV (author)
O'Connell, J (author)
Palmer, ND (author)
Papanicolau, GJ (author)
Pazoki, R (author)
Pedersen, NL (author)
Karolinska Institutet
Peters, A (author)
Poveda, Alaitz (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Polasek, O (author)
Porteous, DJ (author)
Poveda, A (author)
Raitakari, OT (author)
Rich, SS (author)
Risch, N (author)
Robinson, JG (author)
Rose, LM (author)
Rudan, I (author)
Schreiner, PJ (author)
Scott, RA (author)
Sidney, SS (author)
Sims, M (author)
Smith, JA (author)
Snieder, H (author)
Sofer, T (author)
Starr, JM (author)
Sternfeld, B (author)
Strauch, K (author)
Tang, H (author)
Taylor, KD (author)
Tsai, MY (author)
Tuomilehto, J (author)
Uitterlinden, AG (author)
van der Ende, MY (author)
van Heemst, D (author)
Voortman, T (author)
Waldenberger, M (author)
Franks, Paul W. (author)
Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, USA; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Wilson, G (author)
Xiang, YB (author)
Yao, J (author)
Yu, CZ (author)
Yuan, JM (author)
Zhao, W (author)
Zonderman, AB (author)
Becker, DM (author)
Boehnke, M (author)
Bowden, DW (author)
de Faire, U (author)
Karolinska Institutet
Deary, IJ (author)
Elliott, P (author)
Esko, T (author)
Freedman, BI (author)
Froguel, P (author)
Gasparini, P (author)
Gieger, C (author)
Kato, N (author)
Laakso, M (author)
Lakka, TA (author)
Lehtimaki, T (author)
Magnusson, PKE (author)
Karolinska Institutet
Oldehinkel, AJ (author)
Penninx, BWJH (author)
Samani, NJ (author)
Shu, XO (author)
van der Harst, P (author)
Van Vliet-Ostaptchouk, JV (author)
Vollenweider, P (author)
Wagenknecht, LE (author)
Wang, YX (author)
Wareham, NJ (author)
Weir, DR (author)
Wu, TC (author)
Zheng, W (author)
Zhu, XF (author)
Evans, MK (author)
Franks, PW (author)
Gudnason, V (author)
Hayward, C (author)
Horta, BL (author)
Kelly, TN (author)
Liu, YM (author)
North, KE (author)
Pereira, AC (author)
Ridker, PM (author)
Tai, ES (author)
van Dam, RM (author)
Fox, ER (author)
Kardia, SLR (author)
Liu, CT (author)
Mook-Kanamori, DO (author)
Province, MA (author)
Redline, S (author)
van Duijn, CM (author)
Rotter, JI (author)
Kooperberg, CB (author)
Gauderman, WJ (author)
Psaty, BM (author)
Rice, K (author)
Munroe, PB (author)
Fornage, M (author)
Cupples, LA (author)
Rotimi, CN (author)
Morrison, AC (author)
Rao, DC (author)
Loos, RJF (author)
show less...
 (creator_code:org_t)
et al 
2019-01-22
2019
English.
In: Nature communications. - London : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 376-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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art (subject category)

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By the author/editor
Kilpelainen, TO
Bentley, AR
Noordam, R
Sung, YJ
Schwander, K
Winkler, TW
show more...
Jakupovic, H
Chasman, DI
Manning, A
Ntalla, I
Aschard, H
Brown, MR
de las Fuentes, ...
Franceschini, N
Guo, XQ
Vojinovic, D
Aslibekyan, S
Feitosa, MF
Kho, M
Musani, SK
Richard, M
Wang, HM
Wang, Z
Bartz, TM
Bielak, LF
Campbell, A
Dorajoo, R
Fisher, V
Franks, Paul
Horimoto, ARVR
Li, CW
Lohman, KK
Marten, J
Sim, XL
Smith, AV
Tajuddin, SM
Alver, M
Amini, M
Boissel, M
Chai, JF
Chen, X
Divers, J
Evangelou, E
Gao, C
Graff, M
Harris, SE
He, MA
Hsu, FC
Jackson, AU
Zhao, JH
Kraja, AT
Kuhnel, B
Laguzzi, F
Lyytikainen, LP
Nolte, IM
Rauramaa, R
Riaz, M
Robino, A
Rueedi, R
Stringham, HM
Takeuchi, F
van der Most, PJ
V. Varga, Tibor
Verweij, N
Ware, EB
Wen, WQ
Li, XY
Yanek, LR
Amin, N
Arnett, DK
Boerwinkle, E
Brumat, M
Cade, B
Canouil, M
Chen, YDI
Concas, MP
Connell, J
de Mutsert, R
de Silva, HJ
de Vries, PS
Demirkan, A
Ding, JZ
Eaton, CB
Faul, JD
Friedlander, Y
Gabriel, KP
Ghanbari, M
Giulianini, F
Gu, CC
Gu, DF
Harris, TB
He, J
Heikkinen, S
Heng, CK
Hunt, SC
Ikram, MA
Jonas, JB
Wennberg, Patrik ...
Komulainen, P
Krieger, JE
Kritchevsky, SB
Kutalik, Z
Kuusisto, J
Langefeld, CD
Langenberg, C
Launer, LJ
Leander, K
Lemaitre, RN
Lewis, CE
Liang, JJ
Alizadeh, BZ
Boezen, HM
Franke, L
Navis, G
Rots, M
Swertz, M
Wolffenbuttel, B ...
Wijmenga, C
Liu, JJ
Magi, R
Manichaikul, A
Meitinger, T
Metspalu, A
Milaneschi, Y
Mohlke, KL
Mosley, TH
Murray, AD
Nalls, MA
Nang, EEK
Nelson, CP
Nona, S
Norris, JM
Nwuba, CV
O'Connell, J
Palmer, ND
Papanicolau, GJ
Pazoki, R
Pedersen, NL
Peters, A
Poveda, Alaitz
Polasek, O
Porteous, DJ
Poveda, A
Raitakari, OT
Rich, SS
Risch, N
Robinson, JG
Rose, LM
Rudan, I
Schreiner, PJ
Scott, RA
Sidney, SS
Sims, M
Smith, JA
Snieder, H
Sofer, T
Starr, JM
Sternfeld, B
Strauch, K
Tang, H
Taylor, KD
Tsai, MY
Tuomilehto, J
Uitterlinden, AG
van der Ende, MY
van Heemst, D
Voortman, T
Waldenberger, M
Franks, Paul W.
Wilson, G
Xiang, YB
Yao, J
Yu, CZ
Yuan, JM
Zhao, W
Zonderman, AB
Becker, DM
Boehnke, M
Bowden, DW
de Faire, U
Deary, IJ
Elliott, P
Esko, T
Freedman, BI
Froguel, P
Gasparini, P
Gieger, C
Kato, N
Laakso, M
Lakka, TA
Lehtimaki, T
Magnusson, PKE
Oldehinkel, AJ
Penninx, BWJH
Samani, NJ
Shu, XO
van der Harst, P
Van Vliet-Ostapt ...
Vollenweider, P
Wagenknecht, LE
Wang, YX
Wareham, NJ
Weir, DR
Wu, TC
Zheng, W
Zhu, XF
Evans, MK
Franks, PW
Gudnason, V
Hayward, C
Horta, BL
Kelly, TN
Liu, YM
North, KE
Pereira, AC
Ridker, PM
Tai, ES
van Dam, RM
Fox, ER
Kardia, SLR
Liu, CT
Mook-Kanamori, D ...
Province, MA
Redline, S
van Duijn, CM
Rotter, JI
Kooperberg, CB
Gauderman, WJ
Psaty, BM
Rice, K
Munroe, PB
Fornage, M
Cupples, LA
Rotimi, CN
Morrison, AC
Rao, DC
Loos, RJF
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature communica ...
By the university
Karolinska Institutet
Umeå University
Lund University

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